Mdi and tdi dermal penetration studies

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Human danger to methylbenzene diisocyanate (TDI) occurs in the main finished inhalation of vapors in occupational settings wherever TDI is create or used, but stratum vulnerability to TDI is also achievable during few operations. Because of a modern medicine study reportage a feasible association with respiratory organ somebody risk in workers with possible dermal vulnerability to TDI, we evaluated the indicant from epidemiological, toxicological, and toxicokinetic studies to assess whether it is equiprobable that dermal exposure to TDI can cause human metabolic process cancers. We found that the reported associations with respiratory cancers in the medical speciality studies do not assistance TDI as a causal factor, as there are other explanations that are much expected than causation, so much as confounding by smoking and low socioeconomic status.

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Dermal uptake and excretion of 14C-toluene diisocyante (TDI) and 14C-methylene diphenyl diisocyanate (MDI) in male rats. Clinical signs and histopath... - PubMed - NCBI

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Polyurethanes (PU) are polymers ready-made with diisocyanates such as MDI (4,4'-methylene diphenyl diisocyanate) and TDI (2,4-toluene diisocyanate and 2,6-toluene diisocyanate). Investigations person been undertaken with MDI and TDI to value cuticular uptake and ensuant general exposure. Absorption, arrangement and excretion of MDI was studied in rats using a single dermal administration of (14)C-MDI dissolved in resolvent at specified 165 mg/kg body weight and 15 mg/kg bw (4.0 and 0.4 mg/cm(2)) and intracutaneous introduction of (14)C-MDI dissolved in corn oil at nominal 1.4 mg/kg bw.

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Biological monitoring of workers exposed to 4,4′-methylenediphenyl diisocyanate (MDI) in 19 French polyurethane industries | SpringerLink

To report the range of excretory product levels of 4,4′-methylenedianiline (MDA), a matter of methylenediphenyl diisocyanate (MDI), across factories in the polyurethane industries and to value the validness of this biomarker to set MDI occupational exposure. Workers unprotected to MDI, as well as non-occupationally unclothed subjects, were affected and pre- and post-shift urine samples were congregate from 169 workers of 19 nation factories and 120 controls. Details on work activities and practices were concentrated by a form and workers were classified into ternary job categories.

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